1.Thefailureofahigh-profilecholesteroldrughasthrow - 考试试题及答案解析 - 读趣百科
解答题

1.The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels.But many researchers remain confident that drugs to boost levels of 'good' cholesterol are still one of the most promising means to combat spiralling heart disease.

2.Drug company Pfizer announced on 2 December that it was cancelling all clinical trials of torcetrapib,a drug designed to raise heart-protective high-density lipoproteins (HDLs).In a trial of 15000 patients,a safety board found that more people died or suffered cardiovascular problems after taking the drug plus a cholesterol-lowering statin than those in a control group who took the statin alone.

3.The news came as a kick in the teeth to many cardiologists because earlier tests in animals and people suggested it would lower rates of cardiovascular disease."There have been no red flags to my knowledge," says John Chapman,a specialist in lipoproteins and atherosclerosis at the National Institute for Health and Medical Research (INSERM) in Paris who has also studied torcetrapib."This cancellation came as a complete shock."

4.Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs,which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.Specifically,torcetrapib blocks a protein called cholesterol ester transfer protein (CETP),which normally transfers the cholesterol from high-density lipoproteins to low density,plaque-promoting ones.Statins,in contrast,mainly work by lowering the 'bad' low-density lipoproteins.

Under pressure

5.Researchers are now trying to work out why and how the drug backfired,something that will not become clear until the clinical details are released by Pfizer.One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients.It was thought that this mild problem would be offset by the heart benefits of the drug.But it is possible that it actually proved fatal in some patients who already suffered high blood pressure.If blood pressure is the explanation,it would actually be good news for drug developers because it suggests that the problems are specific to this compound.Other prototype drugs that are being developed to block CETP work in a slightly different way and might not suffer the same downfall.

6.But it is also possible that the whole idea of blocking CETP is flawed,says Moti Kashyap,who directs atherosclerosis research at the VA Medical Center in Long Beach,California.When HDLs excrete cholesterol in the liver,they actually rely on LDLs for part of this process.So inhibiting CETP,which prevents the transfer of cholesterol from HDL to LDL,might actually cause an abnormal and irreversible accumulation of cholesterol in the body."You're blocking a physiologic mechanism to eliminate cholesterol and effectively constipating the pathway," says Kashyap.Going up

7.Most researchers remain confident that elevating high density lipoproteins levels by one means or another is one of the best routes for helping heart disease patients.But HDLs are complex and not entirely understood.One approved drug,called niacin,is known to both raise HDL and reduce cardiovascular risk but also causes an unpleasant sensation of heat and tingling.Researchers are exploring whether they can bypass this side effect and whether niacin can lower disease risk more than statins alone.Scientists are also working on several other means to bump up high-density lipoproteins by,for example,introducing synthetic HDLs."The only thing we know is dead in the water is torcetrapib,not the whole idea of raising HDL," says Michael Miller,director of preventive cardiology at the University of Maryland Medical Center,Baltimore.

Questions 7-13

Match torcetrapib,HDLs,statin and CETP with their functions (Questions 8-13)..Write the correct letter A,B,C or D in boxes 8-13 on your answer sheet.NB You may use any letter more than once.

7.It has been administered to over 10,000 subjects in a clinical trial.

8.It could help rid human body of cholesterol.

9.Researchers are yet to find more about it.

10.It was used to reduce the level of cholesterol.

11.According to Kashyap,it might lead to unwanted result if it's blocked.

12.It produced contradictory results in different trials.

13.It could inhibit LDLs.List of choices

A.TorcetrapicB.HDLSC.StatinD.CETP

主观题和计算题请自行在草稿纸上作答

题目答案

7.A

8.B

9.B

10.C

11.D

12.A

13.C

答案解析

7、见第二段。题目中administer一词意为“用药”,subject一词为“实验对象”之意。

8、见第四段“…toraiselevelsofHDLs,whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.”即HDLs的作用最终是将choleserol清除出人体:“…forremovalfromthebody”。

9、见第四段“ButHDLsarecomplexandnotentirelyunderstood.”

10、见第二段“…plusacholesterol-loweringstatin”,即statin是可以降低cholesterol的。

11、见第六段“SoinhibitingCETP,…mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody.

12、见第三段。

13、见第四段“Statins,incontrast,mainlyworkbyloweringthe'bad'low-densitylipoproteins.”

举一反三
解答题

Rogue theory of smell gets a boost

1.A controversial theory of how we smell, which claims that our fine sense of odour depends on quantum mechanics, has been given the thumbs up by a team of physicists.

2.Calculations by researchers at University College London (UCL) show that the idea that we smell odour molecules by sensing their molecular vibrations makes sense in terms of the physics involved.

3.That's still some way from proving that the theory, proposed in the mid-1990s by biophysicist Luca Turin, is correct.But it should make other scientists take the idea more seriously.

4."This is a big step forward," says Turin, who has now set up his own perfume company Flexitral in Virginia.He says that since he published his theory, "it has been ignored rather than criticized."

5.Most scientists have assumed that our sense of smell depends on receptors in the nose detecting the shape of incoming molecules, which triggers a signal to the brain.This molecular 'lock and key' process is thought to lie behind a wide range of the body's detection systems: it is how some parts of the immune system recognise invaders, for example, and how the tongue recognizes some tastes.

6.But Turin argued that smell doesn't seem to fit this picture very well.Molecules that look almost identical can smell very different — such as alcohols, which smell like spirits, and thiols, which smell like rotten eggs.And molecules with very different structures can smell similar.Most strikingly, some molecules can smell different — to animals, if not necessarily to humans — simply because they contain different isotopes (atoms that are chemically identical but have a different mass).

7.Turin's explanation for these smelly facts invokes the idea that the smell signal in olfactory receptor proteins is triggered not by an odour molecule's shape, but by its vibrations, which can enourage an electron to jump between two parts of the receptor in a quantum-mechanical process called tunnelling.This electron movement could initiate the smell signal being sent to the brain.

8.This would explain why isotopes can smell different: their vibration frequencies are changed if the atoms are heavier.Turin's mechanism, says Marshall Stoneham of the UCL team, is more like swipe-card identification than a key fitting a lock.

9.Vibration-assisted electron tunnelling can undoubtedly occur — it is used in an experimental technique for measuring molecular vibrations."The question is whether this is possible in the nose," says Stoneham's colleague, Andrew Horsfield.

10.Stoneham says that when he first heard about Turin's idea, while Turin was himself based at UCL, "I didn't believe it".But, he adds, "because it was an interesting idea, I thought I should prove it couldn't work.I did some simple calculations, and only then began to feel Luca could be right." Now Stoneham and his co-workers have done the job more thoroughly, in a paper soon to be published in Physical Review Letters.

11.The UCL team calculated the rates of electron hopping in a nose receptor that has an odorant molecule bound to it.This rate depends on various properties of the biomolecular system that are not known, but the researchers could estimate these parameters based on typical values for molecules of this sort.

12.The key issue is whether the hopping rate with the odorant in place is significantly greater than that without it.The calculations show that it is — which means that odour identification in this way seems theoretically possible.

13.But Horsfield stresses that that's different from a proof of Turin's idea."So far things look plausible, but we need proper experimental verification.We're beginning to think about what experiments could be performed."

14.Meanwhile, Turin is pressing ahead with his hypothesis."At Flexitral we have been designing odorants exclusively on the basis of their computed vibrations," he says."Our success rate at odorant discovery is two orders of magnitude better than the competition." At the very least, he is putting his money where his nose is.

Questions 5-9

Complete the sentences below with words from the passage.Use NO MORE THAN THREE WORDS for each answer.

5.The hypothesis that we smell by sensing the molecular vibration was made by ______.

6.Turin's company is based in ______.

7.Most scientists believed that our nose works in the same way as our ______.

8.Different isotopes can smell different when ______ weigh differently.

9.According to Audrew Horsfield, it is still to be proved that ______ could really occur in human nose.

主观题和计算题请自行在草稿纸上作答

题目答案

5.Luca Turin

6.Virginia

7.tongue

8.the atoms

9.vibration-assisted electron tunneling

答案解析

5、文章第二,三和七段均可看出Luca的理论即人类的鼻子是通过感觉气味分子的震动来分辨气味的。

6、见第四段。

7、见第五段“Thismolecular'lockandkey'processisthoughttoliebehindawiderangeofthebody'sdetectionsystems:itishowsomepartsoftheimmunesystemrecogniseinvaders,forexample,andhowthetonguerecognizessometastes.”

8、见第八段“Thiswouldexplainwhyisotopescansmelldifferent:theirvibrationfrequenciesarechangediftheatomsareheavier.”

9、见第九段“"Thequestioniswhetherthisispossibleinthenose,"saysStoneham'scolleague,AndrewHorsfield.”句中的代词“this”指句首的“vibration-assistedelectrontunneling”。

解答题

How shops can exploit people's herd mentality to increase sales

1.A TRIP to the supermarket may not seem like an exercise in psychological warfare—but it is.Shopkeepers know that filling a store with the aroma of freshly baked bread makes people feel hungry and persuades them to buy more food than they had intended.Stocking the most expensive products at eye level makes them sell faster than cheaper but less visible competitors.Now researchers are investigating how “swarm intelligence” (that is,how ants,bees or any social animal,including humans,behave in a crowd) can be used to influence what people buy.

2.At a recent conference on the simulation of adaptive behaviour in Rome,Zeeshan-ul-hassan Usmani,a computer scientist from the Florida Institute of Technology,described a new way to increase impulse buying using this phenomenon.Supermarkets already encourage shoppers to buy things they did not realise they wanted: for instance,by placing everyday items such as milk and eggs at the back of the store,forcing shoppers to walk past other tempting goods to reach them.Mr Usmani and Ronaldo Menezes,also of the Florida Institute of Technology,set out to enhance this tendency to buy more by playing on the herd instinct.The idea is that,if a certain product is seen to be popular,shoppers are likely to choose it too.The challenge is to keep customers informed about what others are buying.

3.Enter smart-cart technology.In Mr Usmani's supermarket every product has a radio frequency identification tag,a sort of barcode that uses radio waves to transmit information,and every trolley has a scanner that reads this information and relays it to a central computer.As a customer walks past a shelf of goods,a screen on the shelf tells him how many people currently in the shop have chosen that particular product.If the number is high,he is more likely to select it too.

4.Mr Usmani's “swarm-moves” model appeals to supermarkets because it increases sales without the need to give people discounts.And it gives shoppers the satisfaction of knowing that they bought the “right” product—that is,the one everyone else bought.The model has not yet been tested widely in the real world,mainly because radio frequency identification technology is new and has only been installed experimentally in some supermarkets.But Mr Usmani says that both Wal-Mart in America and Tesco in Britain are interested in his work,and testing will get under way in the spring.

5.Another recent study on the power of social influence indicates that sales could,indeed,be boosted in this way.Matthew Salganik of Columbia University in New York and his colleagues have described creating an artificial music market in which some 14,000 people downloaded previously unknown songs.The researchers found that when people could see the songs ranked by how many times they had been downloaded,they followed the crowd.When the songs were not ordered by rank,but the number of times they had been downloaded was displayed,the effect of social influence was still there but was less pronounced.People thus follow the herd when it is easy for them to do so.

6.In Japan a chain of convenience shops called RanKing RanQueen has been ordering its products according to sales data from department stores and research companies.The shops sell only the most popular items in each product category,and the rankings are updated weekly.Icosystem,a company in Cambridge,Massachusetts,also aims to exploit knowledge of social networking to improve sales.

7.And the psychology that works in physical stores is just as potent on the internet.Online retailers such as Amazon are adept at telling shoppers which products are popular with like-minded consumers.Even in the privacy of your home,you can still be part of the swarm.

Questions 1-6

Complete the sentences below with words taken from the reading passage.Use NO MORE THAN THREE WORDS for each answer.

1.Shopowners realize that the smell of _______________ can increase sales of food products.

2.In shops,products shelved at a more visible level sell better even if they are more _______________.

3.According to Mr.Usmani,with the use of “swarm intelligence” phenomenon,a new method can be applied to encourage _______________.

4.On the way to everyday items at the back of the store,shoppers might be tempted to buy _______________.

5.If the number of buyers shown on the _______________ is high,other customers tend to follow them.

6.Using the “swarm-moves” model,shopowners do not have to give customers _______________ to increase sales.

主观题和计算题请自行在草稿纸上作答

题目答案

1.答案:(freshly baked) bread.

2.答案:expensive.

3.答案:impulse buying.

4.答案:other (tempting) goods/things/products.

5.答案:screen.

6.答案:discounts.

答案解析

1、(第1段第2行:Shoppersknowthatfillingastorewiththearomaoffreshlybakedbreadmakespeoplefeelhungryandpersuadesthemtobuymorefoodthantheyintended.)

2、(第1段第4行:Stockingthemostexpensiveproductsateyelevelmakesthemsellfasterthancheaperbutlessvisiblecompetitors.)

3、(第2段第1句:AtarecentconferenceonthesimulationofadaptivebehaviourinRome,Zeeshan-ul-hassanUsmani,acomputerscientistfromtheFloridaInstituteofTechnology,describedanewwaytoincreaseimpulsebuyingusingthisphenomenon.)

4、(第2段第2句:Supermarketsalreadyencourageshopperstobuythingstheydidnotrealisetheywanted:forinstance,byplacingeverydayitemssuchasmilkandeggsatthebackofthestore,forcingshopperstowalkpastothertemptinggoodstoreachthem.)

5、(第3段第4行:Asacustomerwalkspastashelfofgoods,ascreenontheshelftellshimhowmanypeoplecurrentlyintheshophavechosenthatparticularproduct.Ifthenumberishigh,heismorelikelytoselectittoo.)

6、(第4段第第1句:MrUsmani's“swarm-moves”modelappealstosupermarketsbecauseitincreasessaleswithouttheneedtogivepeoplediscounts.)

解答题

In the earliest stages of man's development he had nomore need of money than animals have.He was content with very simple forms of shelter,made his own rough tools and weapons and could provide food and clothing for himself and his family from natural materials around him.As he became more civilized,however,he began to want better shelter,more efficient tools and weapons,and more comfortable and more lasting clothing than could be provided by his own neighborhood or by the work of his own unskilled hands.For these things he had to turn to the skilled people such as smiths,leather workers or carpenters.It was then that the question of payment arose.

At first he got what he wanted by a simple process ofexchange.The smith who had not the time to look after land or cattle was glad to take meat or grain from the farmer inexchange for an axe or a plough.But as more and more goods which had no fixed exchange value came on the market,exchange became too complicated to be satisfactory.Another problem arose when those who made things wanted to get stocks of wood or leather,or iron,but had nothing to offer in exchange until their finished goods were ready. Thus the difficulties of exchange led by degrees to the invention of money.In some countries easily handled things like seeds or shells were given a certain value and the farmer,instead of paying the smith for a new axe by giving him some meat or grain,gave him so many shells.If the smith had any shells left when he had bought his food,he could get stocks of the raw materials of his trade.In some countries quite large things such as cows or camels or even big flat stones were used for trade.Later,pieces of metal,bearing values according to the rarity of the metal and the size of the pieces,or coins were used.Money as we know it had arrived.

1.Exchange of goods became difficult because _________.

A man became more civilized

B smiths began to look after land or cattle in their spare time

C more and more goods which had no fixed exchange alues came to the marker

D farmers hadn't enough grain or meat to provide for

skilled workers

2.Money was not used until _______.

A paper was invented

B people practiced a simple process of exchange

C nothing could be offered in exchangeD the exchange of one thing for another became too complicated

3.The best title for this passage is _____.

A What is money

B What are money's functions.

C The importance of money

D The beginning of money

主观题和计算题请自行在草稿纸上作答

题目答案

1、C;2、D;3、D

答案解析

暂无解析
解答题

To begin with,"muzak"(音乐广播网 )was intended simplyto createasoothing(安慰)atmosphere.Recently,however,it's ecome big business —thanks in part to recentresearch.Dr.Ronald Milliman,an American marketing expert,hasshown that music can boost sales or increase factory roduction by as much as a third.But,it has to be light music.A fast one has no effect atall on sales.Slow music can increase receipts by 38%.This isprobably because shoppers slow down and have more opportunityto spot items they like to buy.Yet,slow music isn't alway sanswer.Dr.Milliman found,for example,that in restaurants slowmusic meant customers took longer to eat their meals,whichreduced overall sales.So restaurants owners might be welladvised to play up-tempo music to keep the customers moving—unless of course,the resulting indigestion leads tocomplaints!

练习:

1.The reason why background music is so popular isthat ______.

A.it can have a powerful effect on those who hear it

B.it can help to create a soothing atmosphere

C.it can boost sales or increase factory production erywhere

D.it can make customers eat their meals quickly

2.Background music means ________.

A.light music that customers enjoy mostB.fast music that makes people move fast

C.slow music that can make customers enjoy their meals

D.the music you are listening to while you are doingomething

3.Restaurant owners complain about background musicbecause ______.

A.it results in indigestion

B.it increases their sales

C.it keeps customers moving

D.it decreases their sales

4.The word"up-tempo music"probably means_____.

A.slow music

B.fast music

C.light music

D.classical music

主观题和计算题请自行在草稿纸上作答

题目答案

1、B ;2、D ;3、D; 4、B

答案解析

暂无解析
解答题

Intheearlieststagesofman'sdevelopmenthehadnomoreneedofmoneythananimalshave.Hewascontentwithverysimpleformsofshelter,madehisownroughtoolsandweaponsandcouldprovidefoodandclothingforhimselfandhisfamilyfromnaturalmaterialsaroundhim.Ashebecamemorecivilized,however,hebegantowantbettershelter,moreefficienttoolsandweapons,andmorecomfortableandmorelastingclothingthancouldbeprovidedbyhisownneighborhoodorbytheworkofhisownunskilledhands.Forthesethingshehadtoturntotheskilledpeoplesuchassmiths,leatherworkersorcarpenters.Itwasthenthatthequestionofpaymentarose.

Atfirsthegotwhathewantedbyasimpleprocessofexchange.Thesmithwhohadnotthetimetolookafterlandorcattlewasgladtotakemeatorgrainfromthefarmerinexchangeforanaxeoraplough.Butasmoreandmoregoodswhichhadnofixedexchangevaluecameonthemarket,exchangebecametoocomplicatedtobesatisfactory.Anotherproblemarosewhenthosewhomadethingswantedtogetstocksofwoodorleather,oriron,buthadnothingtoofferinexchangeuntiltheirfinishedgoodswereready.Thusthedifficultiesofexchangeledbydegreestotheinventionofmoney.Insomecountrieseasilyhandledthingslikeseedsorshellsweregivenacertainvalueandthefarmer,insteadofpayingthesmithforanewaxebygivinghimsomemeatorgrain,gavehimsomanyshells.Ifthesmithhadanyshellsleftwhenhehadboughthisfood,hecouldgetstocksoftherawmaterialsofhistrade.Insomecountriesquitelargethingssuchascowsorcamelsorevenbigflatstoneswereusedfortrade.Later,piecesofmetal,bearingvaluesaccordingtotherarityofthemetalandthesizeofthepieces,orcoinswereused.Moneyasweknowithadarrived.

1.Exchangeofgoodsbecamedifficultbecause_________.

Amanbecamemorecivilized

Bsmithsbegantolookafterlandorcattleintheirsparetime

Cmoreandmoregoodswhichhadnofixedexchangealuescametothemarker

Dfarmershadn'tenoughgrainormeattoprovidefor

skilledworkers

2.Moneywasnotuseduntil_______.

Apaperwasinvented

Bpeoplepracticedasimpleprocessofexchange

CnothingcouldbeofferedinexchangeDtheexchangeofonethingforanotherbecametoocomplicated

3.Thebesttitleforthispassageis_____.

AWhatismoney

BWhataremoney'sfunctions.

CTheimportanceofmoney

DThebeginningofmoney

主观题和计算题请自行在草稿纸上作答

题目答案

1、C;2、D;3、D

答案解析

暂无解析
模式切换
热门推荐

-----Didyounoticehimcomein?-----No.I________afootb

-----Didyounoticehimcomein?-----No.I________afootballgame.外语类单选题,雅思单选题,阅读单选题...
展开详情

-----AheavysnowhitmostofthepartsofChinainJanuary,2

-----AheavysnowhitmostofthepartsofChinainJanuary,2008.-----____________terriblenews!外语类单选题,雅思单选题,阅读单...
展开详情

Yourdonationscan_____poorchildren____foodandachanc

Yourdonationscan_____poorchildren____foodandachancetostudy.外语类单选题,雅思单选题,阅读单选题...
展开详情

Howshopscanexploitpeople'sherdmentalitytoincreases

Howshopscanexploitpeople'sherdmentalitytoincreasesales1.ATRIPtothesupermarketmaynotseemlikeanexercis...
展开详情

-----Wouldyoumindmyusingyourpen?-----_____________

-----Wouldyoumindmyusingyourpen?-----_______________.外语类单选题,雅思单选题,阅读单选题...
展开详情